Sepsisul este sindromul clinic definit de prezenţa infecţiei şi a răspunsului inflamator sistemic la infecţie (1) şi se caracterizează prin activarea sistemică multiplă a căilor inflamatorii, cu variaţii semnificative şi risc de mortalitate (2, 3). Sepsisul reprezintă dezvoltarea sindromului de răspuns inflamator sistemic în prezenţa infecţiei (4, 5, 6).
Bibliografie
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3. Van der Poll T. Immunotherapy of sepsis. Lancet Infect Dis. 2001 Oct;1(3):165-74
4. Fry DE. Sepsis and multiple organ failure. In: Pollock AV, Evans M (Eds). Postoperative Complications in Surgery. Blackwell Scientific Publications Oxford, 1991; 67-84
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6. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644-55
7. Mancini N, Carletti S, Ghidoli N, Cichero P, Burioni R, Clementi M. The era of molecular and other non-culture-based methods in diagnosis of sepsis. Clin Microb Rev. 2010 Jan; 23(1):235-51
8. Boontham P, Chandran P, Rowlands B, Eremin O. Surgical sepsis: dysregulation of immune function and therapeutic implications. Surgeon 2003 Aug; 1(4):187-206
9. Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol. 2003 Oct;3(10):791-800
10. Opal SM, Cohen J. Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis? Crit Care Med. 1999 Aug;27(8):1608-16
11. Wang Z, Su F, Rogiers P, Vincent JL. Beneficial effects of recombinant human activated protein C in a ewe model of septic shock. Crit Care Med. 2007 Nov;35(11):2594-600
12. Bone RC. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatoty response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med. 1996 Oct 15;125(8):680-7
13. Păunescu V. Progrese înregistrate în tratamentul peritonitelor acute difuze. În: Chira C, Calomfirescu N. Tendinţe actuale de diagnostic şi tratament în practica medicală, Editura Ministerului de Interne, 2002; 364-97
14. Moreno R, Vincent JL, Matos R, MendonÁa A, Cantraine F, Thijs L, Takala J, Sprung C, Antonelli M, Bruining H, Willatts S. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med. 1999 Jul; 25(7):686-96
15. Le Gall JR, Klar J, Lemeshow S., Saulnier F, Alberti C, Artigas A, Teres D. The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA. 1996 Sep 11; 276(10):802-10
16. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197-216
17. Heidecke CD, Weighardt H, Hensler T, Bartels H, Holzmann B. ŞImmune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survivalţ. ŞArticle in Germanţ. Chirurg. 2000 Feb;71(2); 159-65
18. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nature Rev Immunol. 2008 Oct; 8(10)776-87
19. van der Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect Dis. 2008 Jan;8(1):32-43
20. Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol. 2006 Nov;6(11):813-22
21. Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 2005 Apr 15;174(8):5110-8
22. Kelly JL, O’Sullivan C, O’Riordain M, O’Riordain D, Lyons A, Doherty J, Mannick JA, Rodrick ML. Is circulating endotoxin the trigger for the systemic inflammatory response syndrome seen after injury? Ann Surg. 1997 May;225(5):530-41; discussion 541-3
23. Solomkin JS, Jenkins MK, Nelson RD, Chenoweth D, Simmons RL. Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation. Surgery. 1981 Aug;90(2):319-27
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